联系方式

邮箱：guning@hit.edu.cn

个人简介

1998-2002年：日本京都教育大学理学学士

2002-2004年：日本京都大学环境学硕士

2004-2007年：日本京都大学环境学博士

2007-2009年：日本学术振兴会（JSPS）博士后

2009-2010年：日本产业技术研究所博士后

2010-2015年：哈尔滨工业大学生命学院副教授

2016-现在：哈尔滨工业大学生命学院教授

Personal Profile

1998-2002: Japan Kyoto University of EducationBachelor of Science

2002-2004: Japan Kyoto UniversityMaster of Environmental Science

2004-2007: Japan Kyoto UniversityPhD of Environmental Science

2007-2009: Japan Japan Society for the Promotion of Science (JSPS)Postdocs

2009-2010: Japan National Institute of Advanced Industrial Science and TechnologyPostdocs

2010-2015: Harbin Institute of TechnologySchool of Life Science and TechnologyAssistant Professor

2016-now: Harbin Institute of TechnologySchool of Life Science and TechnologyProfessor

研究方向和领域

药理毒理学与内分泌疾病领域的研究

Research Area

pharma-toxicology and endocrine diseases

研究内容

1.糖尿病、肥胖症等内分泌疾病相关基因功能的研究

2.纳米粒子、小分子化合物的药理及毒理研究

3.环境污染物对健康影响及分子机制研究

Research Interests

1.Functions of genes associated with endocrine diseases such as diabetes and obesity

2.Pharmacological and toxicological effects of nanoparticles and small molecule compounds

3.Effects of environment pollutions on health and its molecular mechanisms

研究成果

1. Daqian Yang, Xiaoting Zhang, Lei Yue, Hailong Hu, Xiangjuan Wei, Qian Guo, Boya Zhang, Xingpei Fan, Yuan Xin, Yuri Oh,Ning Gu*. Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression. Chemosphere, 2021, 273:129727.（代表作）

2. Hailong Hu, Qian Guo, Xingpei Fan, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou,Ning Gu*. Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice. Nanotoxicology. 2020 Feb;14(1):59-76.（代表作）

3. Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou,Ning Gu*. Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species. Particle and Fibre Toxicology. 2019, Vol.16:41.（代表作）

4. Qian Guo，Hailong Hu，Ying Zhoua，Yuheng Yan，Xiangjuan Wei，Xingpei Fan，Daqian Yang，Hongjuan He，Yuri Oh，Kun Chen，Qiong Wu，Chuanpeng Liu，Ning Gu*.Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells. Food Chem Toxicol, 2019 March; 125: 95-105.

5. Hu Hailong, Li Li, Guo Qian, Zong He, Yan Yuheng, Yin Yao, Wang Yu, Oh, Yuri, Feng Yujie, Wu Qiong,Ning Gu*.RNA sequencing analysis shows that titaniumdioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 2018 May;12(4):341-356.

6.顾宁*, 胡海龙, 毛轲, 郭倩. 一种促进肌肉细胞中GLUT4基因表达的方法:ZL2014 10076511.1. 2016-09-07.

7.顾宁*, 岳磊，胡海龙, 郭倩, 毛轲.SB505124在制备治疗软骨损伤的药物中的应用: ZL2014 10200906.8. 2016-01-27.

8.顾宁*, 岳磊, 胡海龙. 一种提高人间充质干细胞分化能力的方法: ZL2014 10264739.3. 2016-08-24.

9.顾宁*, 马卓, 胡海龙, 郭倩. 一种检测脏器组织中是否存在纳米颗粒的方法: ZL2014 10465607.7. 2017-01-04.

开设的课程

生物制品

Biologicology

教师个人主页链接

http://homepage.hit.edu.cn/guning