胡颖

1999-2002年：复旦大学（原上海医科大学）生物化学与分子生物学硕士

2002-2004年：香港中文大学临床肿瘤学硕士

2004-2009年：伦敦大学大学学院肿瘤学博士

2009-2011年：牛津大学Ludiwig肿瘤研究所博士后

2012-今：哈尔滨工业大学教授博导

Personal Profile

1994-1999: Shandong Medical UniversityBachelor in Public Health

1999-2002：Fudan UniversityMaster in Biochemistry and molecular biology

2002-2004: The Chinese University of HongKongMaster in Clinical Oncology

2004-2009: University College LondonPhD in cancer biology

2009-2011: Oxford UniversityPostdoctoral Biologist

2012-: Harbin Institute of TechnologyProfessor

研究方向和领域

肿瘤生物学

Cancer Biology

研究内容

耐药和转移是导致肿瘤患者不良预后的重要原因，“肿瘤基因功能研究团队”综合利用细胞生物学，生物化学，分子生物学等研究方法，以小鼠为主要动物模型，结合肿瘤患者标本检测和相关信息分析展开以下研究，为提高肿瘤的治疗效果提供线索，为抑制肿瘤的转移提供新的解释和分子靶点。

1.包括长链非编码RNA在内的癌基因以及抑癌基因的活化机制及功能研究

2.肿瘤与微环境的互作机制研究

Research Interests

Prof. Hu leads the tumor gene function study group with a focus on novel targets that modulate mechanisms of drug resistance and cancer metastasis, the leading reasons for the resultant mortality of patients with cancer. The group currently uses a combination of cellular and molecular strategies, animal tumor models and human samples to work on the following specific issues in the field:

1. The activation and function of oncogenes, as exampled by ASPP family proteins

2.The roles and mechanisms of long non coding RNA (lncRNA) in cancer

3.The interconnection between tumor cell and tumor microenvironment

研究成果

1.Xingwen Wang, Dong Zhao, Hui Xie,Ying Hu*. Interplay of long non-coding RNAs and HIF-1α: A new dimension to understanding hypoxia-regulated tumor growth and metastasis. Cancer Lett. 2021 Feb 28;499:49-59.

2.Kunming Zhao,Ying Hu*. Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment. Signal Transduct Target Ther. 2020 Jul 29;5(1):136.

3.Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi andYing Hu*. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene. 2020 Feb;39(9):1860-1874. Epub 2019 Nov 29.

4.Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li,Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biol. 2020 Mar 23;18(3):e3000666.

5.Huayi Li#, Wenxin Zhang#,Kunming Zhao, Dong Zhao, Shanliang Zheng,Ying Hu*.A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. J Biol Chem. 2020 Mar 20;295(12):4049-4063. Epub 2020 Jan 31.

6.Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu,Ying Hu*.A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death Differ. 2020 Apr;27(4):1431-1446. Epub 2019 Nov 7. CDDPress Monthly Top Picks

7.Huyi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han,Hu Ying*. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer Lett. 2018 Jun 8;432:121-131.8.Wenjie Ge#, Kunming Zhao#,Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang,Ying Hu*.iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell. 2017 Nov 13;32(5):561-573. Epub 2017 Oct 12. Featured article

9.Wang Xingwen, Cheng Yiwei, Zhu Yifu, Li Huayi, Ge Wenjie, Wu Xiaoliang, Zhao Kunming, Yuan J, Li Z, Jiang S, Han Zhengbin, Jiang Qinghua, Wu Qiong, Liu Tao, Zhang Cheng*, Yu Miao*,Hu Ying*. Epigenetic Silencing of ASPP1 confers 5-FU resistance in Clear Cell Renal Cell Carcinoma by preventing p53 activation. Int J Cancer. 2017 Oct 1;141(7):1422-1433. doi: 10.1002/ijc.30852. Epub 2017 Jul 10.

10.Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu, andYing Hu*. EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy. Cell Death Dis. 2017 Jun 8;8(6):e2869. doi: 10.1038/cddis.2017.268.

11.Xingwen Wang, Miao Yu, Kunming Zhao, Mengmeng He,Wenjie Ge,Yuhui Sun,Yihua Wang, Haizhu Sun,Ying Hu*. Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death Dis. 2016 Dec 8;7(12):e2517. doi: 10.1038/cddis.2016.412.

12.L.N. Shao，S. T. Zhang，W. J. Yu，S. H. Zhou，Y. Duan，L. Z. Pan，N. Wang，Ying Hu*，HLA-A, HLA-B, HLA-DRB1 allele and haplotype frequencies of 14,529 Chinese Han bone marrow donors living in Dalian, China.，International Journal of Immunogenetics DOI:10.1111/iji.12248, 2016 Apr;43(2):79-85.doi: 10.1111/iji.12248. Epub 2016 Feb 5.

13.Sun H, Ge W,Gao X, Wang S, Jiang S,Ying Hu*, Yu M* , Hu S*. Apoptosis- Promoting Effects of Hematoporphyrin Monomethyl Ether- Sonodynamic Therapy (HMME-SDT) on Endometrial Cancer. PLoS One. 2015 Sep 14;10(9):e0137980.

14.Zinaida Dedeic#, Gopinath Sutendra#,Ying Hu#, Kathryn Ho Ki Chung, Elizabeth A. Slee, Michael J. White, Felix Zhou, Robert D. Goldin, David J. P. Ferguson, Debra McAndrew, Jurgen E. Schneider and Xin Lu. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell Death and Differentiation, 2018 Jul;25(7):1289-1303.

15.Mario Notari#，Ying Hu#，Sofia Koch，Min Lu，Indrika Ratnayaka，Shan Zhong，Caroline Baer，Anna Pagotto，Robert Goldin，Victoria Salter，Eleonora Candi，Gerry Melino，and Xin Lu*. iASPP prevents premature cellular senescence and is required for normal epithelial stratification. Proc Natl Acad Sci. 2011. 108(40): 16645–16650.

16.Ying Hu，Elizabeth Pang，Paul B.-S. Lai，Jeremy A. Squire，Pascale F. MacGregor，Ben Beheshti，Monique Albert，Thomas W.-T. Leung，Nathalie Wong*，Genetic alterations in doxorubicin-resistant hepatocellular carcinoma cells: a combined study of spectral karyotyping, positional expression profiling and candidate genes.，Int J Oncol，2004.11.1，25（5）：1357~1364.

开设的课程

生物统计学

Biostatistics

生物学基础与应用

Biological Basis and Application

肿瘤生物学进展前沿

Progress and Frontiers in Cancer Research

教师个人主页链接

http://homepage.hit.edu.cn/huying