联系方式
邮箱：huangzhiwei@hit.edu.cn
个人简介
哈工大生命科学与技术学院教授、院长，生命科学中心主任。
2008年从北京生命科学研究所柴继杰教授结构生物学实验室博士毕业，
然后去哈佛大学免疫与感染疾病系 Laurie H. Glimcher教授免疫学实验室做博士后，
2012年回国到哈工大建立实验室，研究微生物和人适应性免疫的分子机制，以及新型基因编辑工具的开发。
Personal Profile
Prof. Huang is dean of the School of Life Science and Technology
and director of HIT Center for Life Sciences at Harbin Instituteof Technology.
After finishing his PhD thesis from the structuralbiology of Dr. Jijie Chai
at National Institute of BiologicalSciences in 2008,
he then went to the immunological lab ofDr. Laurie H. Glimcher
at Harvard University to receive hispostdoctoral training.
In March 2012, he joined the Schooland Life Science and Technologyat Harbin Institute ofTechnology as a professor.
His research mainly focuses onstudyingthe molecular mechanisms of bacterial and humanadaptive immune systems and developing novel genomeeditting tools.
研究方向和领域
采用整合的研究方法包括生物信息学、病毒学、免疫学、结构生物学以及小鼠遗传学等，从分子、细胞以及个体水平等多个层次以较全视野对适应性免疫系统以及病毒拮抗机制进行研究。研究方向包括：
1. 研究人适应性免疫系统以及病毒拮抗宿主免疫的功能与机制。
2. 研究细菌CRISPR-Cas系统以及噬菌体Anti-CRISPR系统的分子机制,同时基于研究成果靶向设计高效的、特异性的新型基因编辑工具。
3. 研究在生理和病理过程中人微生态系统中病毒、细菌的功能与机制。
4. 解析免疫与感染性疾病发生过程中起关键作用的蛋白（复合物）的分子机制，并利用这些结构信息理性设计小分子药物治疗相关疾病。
Research Area
We use multi-disciplinary approaches including bioinformatics, single cell sequencing, immunology, structural biology, and mouse models from to study the molecular mechanisms of microbe and human adaptive immune systems, microbial dysbiosis in human diseases, how immune systems interaction with other systems in the body, and developing novel CRISPR-Cas genome editing tools for the treatment of genetic disorders.
研究成果
1.Hongnan Liu*, Yuwei Zhu*, Zebin Lu,Zhiwei Huang# (2021). Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14. Nucleic Acids Res. 21;49(11):6587-6595.
2.Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*……Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# (2021). COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 184(7):1895-1913.
3.Shengli Ma*#, Fan Zhang*, Fengxia Zhou*, Hui Li*, Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, and Yuhong You,Zhiwei Huang# (2021). Metagenomic analysis reveals throat microbiota alterations in patients with COVID-19. Signal Transduction Targeted Therapy. 6, 191.
4.Fan Zhang*, Rui Gan*, Ziqi Zhen*, Xiaoli Hu*, Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu,Zhiwei Huang# (2020). Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals. Signal Transduction Targeted Therapy. 5(1):156.
5.Kaiming Zhang*, Shuo Wang*, Sahnshan Li*, Yuwei Zhu*, Grigore D. Pintilie, Tung-Chung Mou, Michael F. Schmid,Zhiwei Huang# & Wah Chiu# (2020). Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas. PNAS. 117(13):7176-7182.
6.De Dong*, Lvqin Zheng*, Jianquan Lin*, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao#,Zhiwei Huang# (2019). Structural basis of assembly of the human T cell receptor-CD3 complex. Nature. 573(7775):546-552. (This paper is featured with News & Views, Nature. 573, 502-504 (2019))
7.Liyong Dong*, Xiaoyu Guan*, Ningning Li*, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao &Zhiwei Huang# (2019). An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. 26(4):308-314.
8.Minghui Guo*, Kaiming Zhang*, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu# &Zhiwei Huang# (2019). Coupling of ssRNA Cleavage with DNase Activity in Type III-A CRISPR-Csm Revealed by Cryo-EM and Biochemistry. Cell Research. 29(4):305-312
9.Minghui Guo*, Kuan Ren*, Yuwei Zhu*, Ziyun Tang, Yuhang Wang, Bailing Zhang &Zhiwei Huang# (2019). Structural insights into a high fidelity variant of SpCas9. Cell Research. 29,183-192.
10.Yuwei Zhu,Zhiwei Huang# (2018). Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review. doi: 10.1093/nsr/nwy150
11.Fan Zhang*#, Shijia Zhao*, Chunyan Ren*, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng &Zhiwei Huang# (2018). CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Communications Biology. 31;1:180.
12.De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang,Zhi Xiong, Jianzheng Yang, Zengliang Xu andZhiwei Huang# (2017). Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 546(7658):436-439.
13.Dan Wu*, Xiaoyu Guan*, Yuwei Zhu*, Kuan Ren,Zhiwei Huang# (2017). Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA. Cell Research. 27(5):705-708.
14.Pu Gao, Hui Yang, Kanagalaghatta R Rajashankar,Zhiwei Huangand Dinshaw J Patel (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Research. 26(8):901-13.
15.De Dong*, Kuan Ren*, Xiaolin Qiu*, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao andZhiwei Huang# (2016). Crystal structure of CRISPR-Cpf1 in complex with CRISPR RNA (crRNA). Nature. 532(7600):522-6.
16.Yingying Guo*, Liyong Dong*, Xiaolin Qiu*, Yishu Wang, Bailing Zhang, Hongnan Liu, You Yu, Yi Zang, Maojun Yang andZhiwei Huang# (2014). Structural basis for hijacking CBF-βand CUL5 E3 ligase complex by HIV-1 Vif. Nature. 505(7482):229-33. (This paper is featured with News & Views, Nature. 505, 167-168, highlighted in Nature Structural & Molecular Biology, 21, 117 (2014))
17.Jae-Hyuck Shim, Matthew B. Greenblatt, Weiguo Zou,Zhiwei Huang, Marc N. Wein, Nicholas Brady, Dorothy Hu, Jean Charron, Heather R. Brodkin, Gregory A. Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher and Dallas C. Jones (2013). Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123(9):4010-22.
18.Zehan Hu, Chuangye Yan, Peiyuan Liu,Zhiwei Huang, Rui Ma, Chenlu Zhang, Ruiyong Wang, Yueteng Zhang, Fabio Martinon, Di Miao, Haiteng Deng, Jiawei Wang, Junbiao Chang, Jijie Chai (2013). Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 341(6142):172-5.
19.Weiguo Zou, Xi Chen, Jae Shim,Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher, Dallas Jones (2011). The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13(1):59-65.
20.Zhiwei Huang*, Sarah E. Sutton*, Adam J. Wallenfang, Robert C. Orchard, Xiaojing Wu, Yingcai Feng, Jijie Chai and Neal M. Alto (2009). Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nature Structural & Molecular Biology. 16(8):853-60. (This publication was selected as cover story, and high-lighted by Nature China）
21.Zhiwei Huang, Yingcai Feng, Ding Chen, Xiaojing Wu, Xiaojun Wang, Xingguo Xiao, Wenhui Li, Niu Huang, Lichuan Gu, Guangming Zhong and Jijie Chai (2008). Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host & Microbe. 4(6):529-42. (This publication was selected as a research“highlight”by Nature China）
22.Maikke B. Ohlson,Zhiwei Huang, Neal M. Alto, Jack E. Dixon, Jijie Chai and Samuel I. Miller (2008). Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation. Cell Host & Microbe. 4(5):434-46.
荣誉称号
科学探索奖，2020
国家高层次人才计划，2018
国家杰出青年科学基金，2018
谈家桢生命科学创新奖，2018
中国青年科技奖，2018
国家高层次青年人才计划，2015
国家优秀青年科学基金，2014
黑龙江省杰出青年科学基金，2014
开设的课程
结构生物学概论
Introduction to Structural Biology
生物专业导论
Introduction to Biology
生命BIO-X导论
Introduction of BIO-X
结构分子生物学
Structural Molecular Biology
教师个人主页链接
