联系方式
邮箱：wangcl@hit.edu.cn
个人简介
2000-2004年：兰州大学 理学学士
2004-2009年：兰州大学 理学博士
2009-2012年：哈尔滨工业大学 讲师
2012-2021年：哈尔滨工业大学 副教授
2022年-至今：哈尔滨工业大学 教授
Personal Profile
B.Sc. in Biological Science, 2004, School of Life Science, Lanzhou University, China
Ph.D. in Biochemistry and Molecular Biology, 2009, School of Life Science, Lanzhou University, China
Lecturer, School of Life Science and Technology, Harbin Institute of Technology, China, 2009-2012
Associate Professor, Master's Supervisor, School of Life Science and Technology, Harbin Institute of Technology, China, 2012-2021
Professor, Doctoral Supervisor, School of Life Science and Technology, Harbin Institute of Technology, China, 2022-present
研究方向和领域
神经多肽药物构效关系与活性研究
Structure-Activity Study of Neuropeptides
研究内容
神经多肽药物药理学与行为学活性研究
Neuropeptides Physiology & Pharmacology
内吗啡肽的结构改造与阿片活性研究
Structure-Activity Study of Endomorphinsand their opioid activities
研究成果
1.Yu-zhe Zhang, Meng-meng Wang, Si-yu Wang, Xiao-fang Wang, Wen-jiao Yang, Ya-nan Zhao, Feng-tong Han, Yao Zhang,Ning Gu*,Chang-lin Wang*Novel cyclic endomorphin analogs with multiple modifications and oligoarginine-vector exhibit potent antinociception with reduced opioid-like side effects.Journal of Medicinal Chemistry, 64: 16801-16819, 2021.
2.Zhang YZ, Yang WJ, Wang XF, Wang MM, Zhang Y, Gu N*,Wang CL*, The spinal anti-allodynic effects of endomorphin analogs with C-terminal hydrazide modification in neuropathic pain model.Peptides2020;134:170407.
3.Wang CL*, YangDJ, Yuan BY, Wang Y.C-terminal hydrazide modification changes the spinal antinociceptive profiles of endomorphins in mice.Peptides2018;99:128-133.
4. Yuan BY, Liu WZ, Wang XF, Zhang YZ, Yang DJ,Wang CL*. Endomorphin-1 analogs with oligoarginine-conjugation at C-terminus produce potent antinociception with reduced opioid tolerance in paw withdrawal test.Peptides2018;106:96-101.
5. Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y,Wang CL*, Li Y*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating gliadependent neuronal migration during brain development.Cell Death and Disease2018;9:999.
6.Wang CL*, Qiu TT, Yang DJ, Yuan BY, Han FT, Li L, Gu N. Endomorphin-2 analogs with C-terminal esterification produce potent systemic antinociception with reduced tolerance and gastrointestinal side effects.Neuropharmacology2017;116:98-109.
7.Wang CL*, Yang DJ, Yuan BY, Qiu TT.Antiallodynic Effects of Endomorphin-1 and Endomorphin
8.Wang CL*, Qiu TT, Diao YX, Zhang Y, Gu N. Novel endomorphin-1 analogs with C-terminal oligoarginine-conjugation display systemic antinociceptive activity with less gastrointestinal side effects.Biochimie2015 ;116:24-33.
9.Wang CL*, Xiang Q, Diao YX, Ren YK, Gu N.Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogs in mice.Eur. J. Pain2014;18:1157-1164.
10.Wang CL*, Diao YX, Xiang Q, Ren YK, Gu N.Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in miceEur. J.Pharmacol.2014;738:1-7.
11.Wang CL*, Ren YK, Xiang Q, Wang Y, Gu N, Lu C, Wang R*. Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion.Neuropeptides2013;47:297-304.
12.Wang CL*, Zhou Y, Guo C, Zhang Y, Wang R*.In vivo characterization of intestinal effects of endomorphin-1 and endomorphin
13.王长林，张雨哲，袁碧玉.强啡肽A(1-8)与神经降压素(8-13)相偶联的环化杂合肽及其合成方法和应用，授权公告日：2019.6.11，中国发明专利，专利号：201811126681.0
14.王长林，张雨哲，袁碧玉.多位点修饰的脑啡肽与神经降压素(8-13)相偶联的环化杂合肽及其合成方法和应用，授权公告日：2019.6.11，中国发明专利，专利号：201811125677.2
15.王长林，袁碧玉，杨代军.基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用,授权公告日：2018.11.02，中国发明专利，专利号：201711365284.4
16.王长林，袁碧玉，杨代军.4位苯丙酰胺羟基化修饰的内吗啡肽类似物及其合成方法和应用,授权公告日：2018.10.02，中国发明专利，专利号：201711367596.9
17.王长林，杨代军，袁碧玉.C-末端芳香酯化修饰的内吗啡肽-1类似物及其合成和应用,授权公告日：2018.12.11，中国发明专利，专利号：201711366704.0
开设的课程
生命科学导论(文化素质选修课)
Introduction of Life Science
人体生理学(研究生专业课)
Human Physiology
神经生物学(本科生专业课)
Neurobiology
具有镇痛价值的新型内吗啡肽类似物的阿片生物学活性实验(本科生创新实验课)
Experiments of Opioid Bioactivities of Novel Endomorphin Analogs with Antinociceptive Effects
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