联系方式
邮箱：fanyang115@hit.edu.cn
个人简介
2000-2004年：南开大学化学专业理学学士
2004-2009年：北京大学物理化学专业理学博士
2009-2013年：美国华盛顿大学化学学院博士后
2013-2017年：美国华盛顿大学化学学院研究助理/代理讲师
2017-至今：哈尔滨工业大学生命科学与技术学院副研究员
研究方向和领域
液体核磁共振研究生物大分子相互作用的分子机制
Exploring the molecular basis of RNA recognition by RNP by using solution NMR
研究内容
1.不同RNA结合蛋白对microRNA生成过程调控的结构基础；
2.RRM和zinc finger等RNA结合结构域的理性设计；
3.mRNA前体3’末端加工过程相关蛋白因子与PAS RNA的相互作用关系。
Research Interests
1.The structural basis of the regulation of microRNA processing by protein factors;
2.Engineering RNA-binding proteins and understanding protein-RNA recognition specificity;
3.Structural relationship within protein factors involved in pre-mRNA 3’-end processing.
研究成果
1.Fan Yang, Peter Hsu, Susan Lee, Wen Yang, Derick Hoskinson, Weihao Xu, Claire Moore, Gabriele Varani*. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3’-end processing.RNA23 (1), 98-107, 2017.
2. 2.Yu Chen†, Lorena Zubovic†,Fan Yang†,Katherine Godin, Tom Pavelitz, Javier Castellanos, Paolo Macchi*, Gabriele Varani*. Rbfox proteins regulate microRNA biogenesis by sequence specific binding to their precursors and target downstream Dicer.Nucleic Acids Research44 (9), 4381-4395, 2016.† co-first authors.
3.3.Yu Chen,Fan Yang, Lorena Zubovic, Tom Pavelitz, Wen Yang, Katherine Godin, Suxin Zheng, Paolo Macchi, Gabriele Varani*. Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins.Nature Chemical Biology12 (9), 717-723, 2016.
4.4.Wen Yang†, Peter L. Hsu†,Fan Yang, Jae-Eun Song, Gabriele Varani*. Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in its recognition of 3’-end processing signals.Nucleic Acids Research46 (2), 493-503, 2018.*NAR Breakthrough Article
5.5.Maria L. Romero Romero, Fan Yang, Yu-Ru Lin, Agnes Toth-Petroczy, Igor N. Berezovsky, Alexander Goncearenco, Wen Yang, Alon Wellner, Fanindra Kumar-Deshmukh, Michal Sharon, David Baker, Gabriele Varani, and Dan S. Tawfik*. Simple yet functional phosphate-loop proteins.Proceedings of the National Academy of Sciences115 (51), E11943-E11950, 2018.
6.6.Corey M Nemec,Fan Yang, Joshua M. Gilmore, Corinna Hintermair, Yi-Hsuan Ho, Sandra C. Tseng, Martin Heidemann, Ying Zhang, Laurence Florens, Audrey P. Gasch, Dirk Eick, Michael P. Washburn, Gabriele Varani, and Aseem Z. Ansaria*. Different phospho-isoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner.Proceedings of the National Academy of Sciences114 (20), E3944-E3953, 2017.
7.7.Ravi P. Barnwal,Fan Yang, and Gabriele Varani*. Applications of NMR to structure determination of RNAs large and small.Archives of Biochemistry and Biophysics628, 42-56, 2017.
88.Anna Bochicchio, Miroslav Krepl*, Fan Yang, Gabriele Varani, Jiri Sponer, Paolo Carloni*.Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study.PLOS Computational Biology14 (12), e1006642, 2018.
开设的课程
工程伦理
Engineering Ethics
细胞中的社交网络-生物大分子相互作用
Inter-biomolecular Social Networking
教师个人主页链接
http://homepage.hit.edu.cn/fanyang
