联系方式
邮箱：yangkuikun@hit.edu.cn
个人简介
2006-2010年：中国海洋大学生物技术学士
2010-2013年：中国海洋大学生物化学与分子生物学硕士
2013-2018年：马里兰大学学园市分校化学博士
2019-2021年：美国国立卫生研究院/澳门大学 生物材料方向博士后
2021-至今：哈尔滨工业大学教授
Personal Profile
2006-2010:BScDegree in Biotechnology, College of Marine Life Science, Ocean University of China
2010-2013:MScDegree in Biochemistry,College of Marine Life Science, Ocean University of China
2013-2018: PhDin Chemistry,Department of Chemistry and Biochemistry,University of Maryland, College Park
2019-2021: Postdoctoral Fellow,National Institutes of Health/University of Macau
Since 2021: Harbin Institute of Technology, Professor of Biology and Biomedical Engineering
研究方向和领域
智能纳米组装材料的设计，构建及其生物医学应用
Design, construction and biomedical applications of smart nanoassemblies
研究内容
1.高分子聚合物-无机纳米粒杂化组装单元的设计和制备
2.纳米组装结构的精准控制和自组装动力学研究
3.超分子组装纳米载体的设计和生物医学应用
4.仿生智能高分子材料在肿瘤治疗诊断中的应用
Research Interests
1.Design and synthesis ofhybrid polymer-inorganic nanoparticlesas building blocks for self-assembly.
2.Well-controlled self-assembly of nanostructures and the fundamental thermodynamic/kinetic research on the assembly process.
3.Design and functionalization of nanoscale biomedical materials.
4.Supramolecular self-assemblies as delivery vehicles for a variety of biomedical applications including bioimaging, diagnosis and therapy of tumors.
研究成果
1.Kuikun Yang,#Yijing Liu,#Yi Liu, Qian Zhang, Chuncai Kong, Chenglin Yi, Zijian Zhou, Zhantong Wang, Guofeng Zhang, Yang Zhang, Niveen M. Khashab,* Xiaoyuan Chen*and Zhihong Nie*, Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery.J. Am. Chem. Soc.2018, 140, 4666. (ESI Highly cited paper, IF: 15.419)
2.Kuikun Yang,#Guocan Yu,#Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen* and Ruibing Wang*, Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumour.Angew. Chem. Int. Ed.2021, 60, 17570. (IF: 15.336)
3.Kuikun Yang,#Guocan Yu,#Rui Tian, Zijian Zhou, Hongzhang Deng*, Ling Li, Zhen Yang, Guofeng Zhang, Dahai Liu, Jianwen Wei, Ludan Yue, Ruibing Wang* and Xiaoyuan Chen*,Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy.Adv. Funct. Mater.2021, 31, 2008078. (IF: 18.808)
4.Kuikun Yang,#Ludan Yue,#Guocan Yu, Lang Rao, Rui Tian, Jianwen Wei, Zhiqing Yang,#Chen Sun, Xiangjun Zhang, Mengze Xu, Zhen Yuan, Xiaoyuan Chen* and Ruibing Wang*, A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy.Biomaterials.2021, 275, 120822. (IF: 12.479)
5.Kuikun Yang,#Yijing Liu,#Yin Wang,#Qilong Ren, Hongyu Guo, John B. Matson, Xiaoyuan Chen* and Zhihong Nie*, Enzyme-inducedin vivoassembly of gold nanoparticles for imaging-guided synergistic chemo-photothermal therapy of tumor.Biomaterials. 2019, 223, 119460. (IF: 12.479)
6.Kuikun Yang,#Shaoyi Zhang,#Jie He and Zhihong Nie*, Polymers and Inorganic Nanoparticles: A Winning Combination towards Assembled Nanostructures for Cancer Imaging and Therapy.Nano Today.2021, 36, 101046. (IF: 20.722)
7.Kuikun Yang,#Zhiqing Yang,#Guocan Yu*, Ruibing Wang* and Xiaoyuan Chen*, Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy.Adv. Mater.2021,In press.(IF: 30.849)
8.Haihang Ye,#Kuikun Yang(equal contribution),#Jing Tao, Yijing Liu, Qian Zhang, Sanaz Habibi, Zhihong Nie* and Xiaohu Xia*, An Enzyme-Free Signal Amplification Technique for Ultrasensitive Colorimetric Assay of Disease Biomarkers.ACS Nano.2017, 11, 2052. (IF: 15.881)
9.Qilong Ren,#Kuikun Yang (equal contribution),#Rujia Zou, Zhiping Wan, Zheyu Shen, Guangyu Wu, Zijian Zhou, Qianqian Ni, Wenpei Fan, Junqing Hu* and Yijing Liu*, Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics.Nanoscale. 2019, 11, 23021. (IF: 7.79)
10.Di Zheng,#Kuikun Yang (equal contribution)#and Zhihong Nie*, Engineering heterogeneity of precision nanoparticles for biomedical delivery and therapy.View.2021, 20200067. (IF: N/A)
教师个人主页链接
http://homepage.hit.edu.cn/Yangkuikun
